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🚨 A new option for acute pain is finally here. In January 2025, the FDA approved Journavx (suzetrigine)—the first new class of pain medication in more than 20 years. Unlike NSAIDs or opioids, suzetrigine works by blocking the NaV1.8 sodium channel, interrupting pain signals in the peripheral nerves before they reach the brain. ✅ FDA-approved for moderate-to-severe acute pain (not chronic pain) ✅ Non-opioid mechanism ✅ No evidence of respiratory depression, addiction, or physical dependence in c
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Administering low-dose intravenous ketamine transforms multimodal general anesthesia by targeting central pain pathways before surgical stimulation begins. Ketamine functions as a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, dampening dorsal horn wind-up and preventing acute central sensitization (Peltoniemi et al., 2016). When combined synergistically with gamma-aminobutyric acid (GABA) receptor agonists like propofol, it produces reliable hypnotic depth and somatic analgesia
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The FDA has approved a first-of-its-kind pill for pancreatic cancer, which kills about 50,000 Americans a year. Former Sen. Ben Sasse told @60minutes earlier this year that he was part of the clinical trial, calling the pill a “miracle drug.” Dr. Celine Gounder shares about what the medication targets — and how much it is expected to cost.
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