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Exenatide fue el primer agonista del receptor de GLP-1 que se aprobó para el tratamiento de la diabetes tipo 2 en 2005. Su nombre comercial era Byetta y se inyectaba 2 veces al día. En 2010 llegó liraglutide. Inicialmente se comercializó con el nombre de Victoza y estaba indicado para el tratamiento de la diabetes tipo 2. En 2015 se aprobó su uso para el tratamiento de la obesidad bajo el nombre comercial de Saxenda. Supuso un avance frente a exenatide ya que la inyección se administraba una vez
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Crazy to think the entire GLP-1 class started with a chunky desert lizard that barely eats. Scientists discovered the Gila monster’s GLP-1 stayed active far longer than ours—leading to the creation of exenatide (Byetta), and eventually to liraglutide, semaglutide, tirzepatide, and the next wave of advanced incretin therapies. From reptile biology to metabolic breakthroughs—this is one of the coolest stories in modern medicine. #GLP1 #GilaMonster #Exenatide #Byetta #Liraglutide #Semaglutide #Tirz
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