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Metformin Side Effect Your Dr. Didn’t Tell You Dr. Janine speaks specifically to the side effects associated with metformin, a drug taken to normalize blood sugar and potentially promote longevity. She highlights how using metformin can bring about deficiencies in vitamin B12 leading to fatigue, nerve issues, or vision problems. To combat this occurrence, Dr. Janine advises taking a high quality, whole food-sourced adenosylcobalamin (also known as cobamamide on labels) supplement for optimal hea
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For over 60 years, we thought metformin worked mainly through the liver and gut. But new research suggests the brain may play a major role too. This study identified a specific brain pathway (Rap1 in the hypothalamus) that appears critical to metformin’s glucose-lowering effects, potentially reshaping how we understand one of the world’s most prescribed diabetes medications. Source: Sci. Adv. 2025;11:eadu3700
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