Four larger-than-life best friends battle morbid obesity using hard work, heart and a wicked sense of humor.

1000-lb Best Friends: Meet Two New Additions to the Crew! You can never have too many best friends! Catch a brand-new season of 1000-lb Best Friends, every Tuesday at 10/9c.

Click through photos of Vannessa's progress and watch her on 1000-lb Best Friends!

The Latest Vannessa and Jacob's Smoothie Recipes 1000-lb Best Friends Top BFF Moments 1000-lb Best Friends' Favorite Foods Hairstyles High Fashion 1000-lb Best Friends Videos

Watch 1000-lb Best Friends Videos from TLC.com

Jaz and Nesha went from roommates to best friends and were each other's best supporter. Jaz wanted to change her life, get outside more, and improve her health in order to be the best mom she could be.

The best moments from the best of friends! Click through our favorite BFF memories and catch the ladies in a brand-new season of 1000-lb Best Friends, every Wednesday at 4 at 10/9c!

1000-lb Best Friends' Meghan, Tina, Ashely, and Vannessa shared some of their favorite foods. Now, you can cook up healthy alternatives to those dishes with recipes from Taylor Rizzo, RDN, LDN, who …

A First Look at the New TLC Series: 1000-lb Roomies These roomies turned besties are ready to kickstart their joint health journey. Get a first look at their story and watch it unfold on 1000-lb …

Delicious smoothie recipes from 1000-lb Best Friends' Vannessa and her son, Jacob.