The primary safety risks associated with gene therapy include immune reactions and off-target effects in unintended organs, such as the liver, lungs, and spleen. Nevertheless, Ali and Townsend note ...

Targeted rewriting of the epigenome promises to overcome several challenges in direct gene editing in patient therapies.

From new payload linkers to artificial intelligence partnerships, advances in ADC pipelines push forward selective cancer therapies that minimize side effects.

Circular RNA may be part of the solution. Because circular RNA has no ends to degrade—unlike linear RNA—the molecule is more stable and its half-life is extended.

The breakome is a new layer in the multiomics landscape—alongside the genome, transcriptome, proteome, and interactome. While it hasn’t traditionally been included among these other omics, we consider ...

Novel sponge developed by Takara Bio USA enables effective preparation of T cells for CAR T-cell therapy research from primary PBMC samples.

Advances in instruments and tools, as well as focused collaborations, improve accuracy and extend the range of applications.

Regions face reduced federal research funding and shrinking venture capital for startups, though rankings stay consistent.

Stem cells differentiated into brain and neural organoids may help scientists understand both brain development and ...

Novel allogeneic stem cells and differentiated iPSCs are providing more physiologically relevant disease models.

Genetics and drug discovery had its origins in the 1980s with the development of positional cloning technology—that is, using genetic markers to map and identify the genes responsible for Mendelian ...

These soluble protein agonists can replicate Notch activation in suspension culture, opening the door to scalable T-cell therapies.