Background Motor and cognitive dysfunctions are common and disabling features in multiple sclerosis (MS) that remain challenging to treat. Here, we aimed to explore the effect of exergames as a ...
Among a small cohort of individuals with MS, those aged older than 55 years demonstrated greater impaired verbal functioning ...
The results reinforce the need for individualized, biology-driven therapeutic decisions in patients with MS. SAN DIEGO – Older patients with MS had increased neuroaxonal and astroglial injury ...
Background Tuberous sclerosis complex (TSC) is a genetic disease characterised by the growth of benign tumours. The Tuberous sclerosis Associated Neuropsychiatric Disorders (TAND) Checklist is used to ...
The dazzling 36-month clinical data announced by uniQure (NASDAQ: QURE) showing a significant slowing of Huntington’s disease (HD) progression in patients treated with its gene therapy candidate ...
People with multiple sclerosis (MS) seem to experience significant changes in cognition more than a year before significant physical decline is evident, a study found. While measures of processing ...
The last time I wrote an article on uniQure N.V. (QURE), it was in a Seeking Alpha article entitled "uniQure: AMT-130 For HD Progresses Forward With Q2 2025 FDA Meeting." With respect to that article, ...
~ Pivotal study met primary endpoint; high-dose AMT-130 demonstrated statistically significant 75% disease slowing at 36 months as measured by cUHDRS compared to a propensity score-matched external ...
uniQure is targeting a BLA submission in the first quarter of 2026. Topline data were announced from a pivotal phase 1/2 study evaluating AMT-130 in patients with Huntington disease (HD). AMT-130 is a ...
uniQure reported positive topline data from the pivotal Phase I/II study of AMT-130 for the treatment of Huntington’s disease. The study met its prespecified primary endpoint, with high-dose AMT-130 ...
This important manuscript presents a novel application of the SANDI (Soma and Neurite Density Imaging) model to study microstructural alterations in the basal ganglia of individuals with Huntington's ...
Idiopathic normal-pressure hydrocephalus is a neurologic disorder characterized by impaired gait, balance, cognition, and bladder control in older adults. The disorder is treated with shunt surgery, ...
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