Figure 1: The PDK1–PDP2–PDH axis is deregulated in OIS. In conclusion, by metabolic profiling and subsequent functional perturbations of a key metabolic axis, we unveil that PDH, a gatekeeper linking ...
Indications: Pyruvate dehydrogenase complex deficiency, typically associated with post-prandial lactic acidemia with a normal lactate/pyruvate ratio, can be assayed in freshly isolated blood ...
Lung cancer, notorious for its high mortality rates, is a leading cause of cancer-related deaths globally, with metastasis being the primary contributor to poor patient outcomes. A critical factor in ...
The pyruvate dehydrogenase complex consists of many different enzymes (marked in different colours). Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to ...
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The tricarboxylic acid cycle: Oxidation in the round
Having considered localization of respiratory functions in mitochondria and in prokaryotic cells, it’s time to return to the eukaryotic context and follow a molecule of pyruvate across the inner ...
Lung cancer, notorious for its high mortality rates, is a leading cause of cancer-related deaths globally, with metastasis being the primary contributor to poor patient outcomes. A critical factor in ...
Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and ...
Pyruvate is produced by glycolysis, a process in which carbohydrates are broken down to create energy. Calcium pyruvate is a popular supplement that many people use primarily for its purported weight ...
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