SMU looks to stop its five-game skid when the Mustangs play Louisville. Thursday's matchup is the first of the season for the two squads.

SMU comes into a matchup with Louisville as losers of three straight home games. The teams play Thursday for the first time this season.

Take a look at how the Cardinals stack up against the Mustangs for their Tuesday matchup, and who the statistical models favor:

Analyzing Tuesday’s Louisville at SMU odds and lines, with college basketball expert picks, predictions and best bets.

SMU football played a soft ACC schedule last season, while Louisville played the toughest slate. It'll be a bit more even for the top teams in 2025.

Cal faces SMU. Our college basketball odds series has our Cal SMU prediction, odds and pick for Wednesday. ClutchPoints is not affiliated with, endorsed by, or in any way connected to any sportsbook. Gambling is not offered on this website in any form.

Wake Forest Demon Deacons (15-5, 7-2 ACC) at Louisville Cardinals (15-5, 8-1 ACC) Louisville, Kentucky; Tuesday, 7 p.m. EST BETMGM SPORTSBOOK LINE: Cardinals -7.5; over/under is 142 BOTTOM LINE: No. 21 Louisville faces Wake Forest after Reyne Smith scored 30 points in Louisville's 98-73 victory over the SMU Mustangs.

The forward has dealt with a broken thumb for the last month, and had to sit the Cardinals' previous game vs. Virginia.

Pat Kelsey wanted to talk SMU’s ability to win five of its seven Atlantic Coast Conference games for coach Andy Enfield

Louisville celebrated its return to the AP Top 25 in a big way Tuesday night in Moody Coliseum in Dallas, obliterating SMU with a dazzling performance in an astonishing 98-73

Kentucky; Tuesday, 7 p.m. EST BOTTOM LINE: No. 25 Louisville hosts Wake Forest after Reyne Smith scored 30 points in Louisville's 98-73 win against the SMU Mustangs. The Cardinals are 8-3 on their ...

After going 9-4 in 2024, Louisville football is set to begin the 2025 ACC schedule by facing Pitt on Sept. 27 at Acrisure Stadium.