The 49ers announced on Thursday that starting quarterback Brock Purdy will miss several weeks due to an injury.

San Francisco 49ers HC Kyle Shanahan spoke to reporters about their former UFL star backup QB now that Brock Purdy will miss the Saints game.

The New Orleans Saints are set to face off against the San Francisco 49ers in Week 2 and it sounds like New Orleans has an advantage. New Orleans already annou

Jauan Jennings had a positive injury update while star teammate George Kittle will be on the sidelines indefinitely.

USA Today's NFL experts make their picks for a Week 2 showdown between the New Orleans Saints and San Francisco 49ers

The San Francisco 49ers' injury situation looks much better on their first practice report than it did at the end of the preseason.

Kittle suffered a hamstring injury during his team's season opener against the Seattle Seahawks on Sunday and will not return to the game. George Kittle is out for the rest of today’s game due to a hamstring injury. He logged four catches for 25 yards and a touchdown before exiting.

George Kittle mentioned that the first episode of the Kittle’s podcast will be released on Tuesday, Sept. 9. They will be releasing the first episode after the San Francisco 49ers play their first game of the NFL season. The 49ers will play the Seattle Seahawks on Sunday at 4:05 p.m. ET.

Set your Week 2 fantasy football lineups for Sunday action. Click to read start 'em, sit 'em advice, injury inactive news, and pregame reports that provide insider fantasy tips.

The San Francisco 49ers (1-0) hit the road to match up against the New Orleans Saints (0-1) at Caesars Superdome on Sunday, September 14, 2025. Date: Sept. 14

Quarterback Brock Purdy and tight end George Kittle both suffered injuries in Week 1's win over the Seattle Seahawks, and both Pro Bowlers are expected to miss multiple weeks of action. Purdy is on track to be sidelined anywhere from two to five weeks while nursing a variation of turf toe,