Week 2 will serve up four more prime-time games, but the main event will be the Eagles-Chiefs Super Bowl rematch in Kansas City.

The SportsLine Projection Model has locked in its top Week 2 NFL anytime TD picks for players like De'Von Achane and Ja'Marr Chase

Our writers and editors pick winners in all 16 games, including a Thursday night showdown between NFC contenders.

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Injuries are already biting the San Francisco 49ers after two of their top players were dinged up last week in the season-opening win over the Seattle Seahawks, yet the Niners are still 3-point favorites and popular NFL survivor picks in Week 2 as they visit the New Orleans Saints.