Randomized controlled trials have generally shown a benefit from accelerated radiotherapy in head and neck squamous cell carcinoma (HNSCC). However, the large randomized United Kingdom trial CHART ...

Cells adapt to hypoxia by a cellular response, where hypoxia-inducible factor 1a (HIF-1α) becomes stabilized and directly activates transcription of downstream genes. In addition to this "canonical" ...

Scientists spent decades uncovering the mechanisms that regulate the human body’s response to oxygen. The implications on the way we understand disease could be significant. This article was produced ...

Radiation is used to treat a variety of tumors and the response of tumors to radiation is dependent on endothelial cell death, which in turn limits oxygen delivery to the tumor, causing hypoxia and ...