Nature

Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds

Despite considerable advances, and the abundance of organometallic reagents developed for additions to carbonyl compounds, three key challenges have endured. First, the dependence on stoichiometric, ...
Phys.org

Iron catalyst drives asymmetric 1,6 addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds

Scientists at the Institute of Science Tokyo (Science Tokyo) have successfully realized the highly selective asymmetric 1,6 addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl ...
Nature

Organometallic Synthesis of Carbonyl Compounds

The organometallic synthesis of carbonyl compounds encompasses a broad array of methods that employ metal–carbon bonds to construct, modify or elaborate aldehydes, ketones, esters and related ...
EurekAlert!

Highly selective asymmetric 1,6-addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds

The reaction utilizes an iron catalyst together with an N-heterocyclic carbene (NHC) ligand, which suppresses unwanted side reactions to promote highly selective nucleophile addition. In organic ...