For the millions of people living with genetic diseases like muscular dystrophy and inherited liver disorders, one of the ...

A research team led by geneticist Jeannie Lee at Harvard Medical School, cell biologist Jeanne Lawrence at UMass Chan Medical ...

A modified version of CRISPR-Cas9 has enabled, for the first time, the efficient integration of a large transgene capable of inactivating entire chromosomes into one of the three copies of chromosome ...

Explore how gene drives in genetically modified mosquitoes could revolutionize malaria control and combat this deadly disease ...

Scientists are laying the groundwork for treating one of the most common genetic conditions in humans. Research out today ...

The last time The Lancet Microbe featured an Editorial on CRISPR was in November 2020, to mark that year’s Nobel Prize in Chemistry, jointly awarded to Emmanuelle Charpentier and Jennifer A Doudna for ...

A compact Cas12f nuclease shows high editing efficiency in human cells, with structural insights enabling an engineered variant potentially suited for future AAV‑compatible delivery.

CRISPR functions as a programmable genetic memory system derived from bacterial immune defenses against viral infections. Guide RNA allows for rapid multiplexed targeting compared to older ...

Scientists have taken an important step toward a gene therapy that could one day turn off the extra genetic material that ...