The raw material for de novo fatty acid synthesis is acetyl-CoA, which can be obtained via the citrate shuttle pathway or from acetic acid. ACC and FASN catalyze the conversion of acetyl-CoA into ...

Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists. The findings, ...

Insufficient acetyl-CoA derails the immune system's ability to protect the body. Until now, however, it was unclear exactly how immune cells maintained their acetyl-CoA reserves. In their new study, ...