The 49ers face major setbacks with Brock Purdy sidelined by turf toe and George Kittle on IR, leaving Mac Jones to keep San Francisco’s playoff hopes alive.

After a mostly healthy 2024 season, San Francisco 49ers quarterback Brock Purdy's status is in question heading into Week 2.

Left tackle Trent Williams was listed as a non-participant in Wednesday's session because of a knee injury, as well as his typical veteran rest day. He was once again a non-participant Thursday, bringing his availability for Week 2 into question.

The New Orleans Saints need to add a wide receiver to their offense in order to help quarterback Spencer Rattler have a fair chance to succeed. In Week 1, Rattl

The star tight end suffered a hamstring injury in the first half of the San Francisco 49ers' matchup against the Seattle Seahawks on Sunday and was ruled out of the rest of the game, the team announced. Kittle had put together a strong start to the Week 1 contests, recording four catches for 25 yards and a touchdown.

These 49ers-Saints bold predictions will go over the status of these injuries, as well as others who benefit from them. Additionally, it will discuss past results and how they relate to this 49ers vs. Saints game. It's time for a 49ers-Saints Week 2 preview, featuring three bold predictions that could come true this weekend.

The San Francisco 49ers and Seattle Seahawks will meet on Sunday for a Week 1 battle. Here's what fans should know heading into the game.

Get a prediction, pick and odds for the NFL Week 2 matchup between the San Francisco 49ers and the New Orleans Saints.

New Orleans Saints head coach Kellen Moore speaks with the media ahead of Week 2 vs. the San Francisco 49ers from the Ochsner Sports Performance Center on Friday, September 12, 2025.