Directed and written by Coralie Fargeat, the film follows the story of TV star and aerobics instructor Elisabeth Sparkle (Moore), who is fired from her own show on her 50th birthday by her boss, Dennis Quaid's cartoonishly misogynist TV exec Harvey – a not-even-slightly-subtle iteration of disgraced abuser Harvey Weinstein.

The Substance, the new film starring Margaret Qualley and Demi Moore, has set a record for the latter. The body-horror film follows a fading celebrity (played by Moore) who begins to use a black-market drug that creates a younger version of herself (Qualley).

From daunting high-energy choreography to nine-hour prosthetic application, the stars tell EW "The Substance" was a satisfyingly grueling, months-long shoot.