The Detroit Lions take on the Buffalo Bills at Ford Field Sunday in what many are calling a possible Super Bowl preview.

It's Buffalo Bills vs Detroit Lions in Week 15 of the NFL season. Can Josh Allen and company outduel Jared Goff and Amon-Ra St. Brown?

Nolan Bianchi, John Niyo, Richard Silva and Bob Wojnowski of The Detroit News offer predictions for Sunday's Lions-Bills game at Ford Field.

DETROIT – The Detroit Lions snapped an 11-game winning streak Sunday, falling to the Buffalo Bills in a high-scoring shootout that saw the Lions twice attempt an onside kick.

Loss number two is in the books for the Detroit Lions. Their tilt with the Buffalo Bills was expected to be a high-scoring affair, and a 48-42 score line certainly lived up to it. Unfortunately, Detroit was not on the right side of this one,

Everything we know from Detroit’s painful loss to Buffalo in Week 15, including stats, stars, injuries and more

The Buffalo Bills (10-3) take on the Detroit Lions (12-1) Sunday in Week 15. Kickoff from Ford Field is set for 4:25 p.m. ET (CBS). Below, we look at Bills vs. Lions odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

Here’s the preview, odds, best bets, and expert predictions for the upcoming Buffalo Bills vs. Detroit Lions game.

Kickoff is on Sunday, Dec. 15, at 4:25 p.m. ET on CBS. The Detroit Lions will host the Buffalo Bills at Ford Field for a highly anticipated game.

The Buffalo Bills are heading into their Week 17 AFC East showdown against the New York Jets with a 12-3 record. They are still fresh off of a tight 24-21 win over the New England Patriots last week.

Lions ascend as Chiefs & Bills recalibrate. Detroit's dynamic offense could fuel their triumph. Dubbs and Donnie break it down.