Niles is a city in southern Trumbull County, Ohio, United States, situated at the confluence of the Mahoning River and Mosquito Creek. The city'…Niles is a city in southern Trumbull County, Ohio, United States, situated at the confluence of the Mahoning River and Mosquito Creek. The city's population was 18,443 at the 2020 census. It is a suburb of the Youngstown–Warren metropolitan area.